What is the clinical evidence from this study?

Study design: Cohort. Population: Coronary Heart Disease (n=214108). Intervention: Lignan intake vs. Lowest quintile of intake. Primary outcome: Coronary heart disease (CHD) (HR 0.85, 95% CI 0.79-0.92, p=≤0.003).

What question did this study set out to answer?

To prospectively examine the association between dietary lignan intake and the risk of coronary heart disease in adults.

August 11, 2026Journal of the American College of CardiologyOpen Access

Lignan Intake and Risk of Coronary Heart Disease

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Key result

Higher total lignan intake is linked to ~15% lower coronary heart disease risk.

HR 0.85
95% CI 0.79-0.92
P≤0.003
n=214,108

Why the study?

Does increased lignan intake reduce the risk of coronary heart disease in adults without prior cardiovascular disease or cancer?

Population

214,108 U.S. men and women in three cohorts who did not have cardiovascular disease or cancer at baseline.

Comparison

Higher lignan intake assessed via food frequency… vs Lower lignan intake (comparing extreme quintiles).

Design

Cohort

Follow-up

5,517,225 person-years

Authors

YHYang HuTongji University YLYanping LiBGI Group (China)LSLaura SampsonBoston University

Discussion

Member takes

Implication

Increased long-term dietary intake of lignans is associated with a significantly lower risk of coronary heart disease, with potential synergistic benefits when combined with higher fiber intake.

Key Points

To prospectively examine the association between dietary lignan intake and the risk of coronary heart disease in adults.
Followed 214,108 men and women across three U.S. cohorts without baseline cardiovascular disease or cancer over 5,517,225 person-years.
Assessed long-term diet repeatedly every 2 to 4 years using validated food frequency questionnaires.
Documented 10,244 total CHD cases (6,283 non-fatal myocardial infarctions and 3,961 fatal CHD cases).
Comparing extreme quintiles, multivariable-adjusted HRs for CHD were 0.85 (95% CI: 0.79–0.92) for total lignans, 0.76 (95% CI: 0.71–0.82) for matairesinol, 0.87 (95% CI: 0.81–0.93) for secoisolariciresinol, 0.89 (95% CI: 0.83–0.95) for pinoresinol, and 0.89 (95% CI: 0.83–0.95) for lariciresinol (all p for trend ≤ 0.003).
Risk reductions plateaued non-linearly above intakes of ~300 μg/d for total lignans, with inverse associations appearing stronger among participants with higher fiber intake (p=0.04 for interaction).

Study Design

Type

Cohort (n=214,108)

Multicenter

Yes

Structured PICO

Does increased lignan intake reduce the risk of coronary heart disease in adults without prior cardiovascular disease or cancer?

Population

214,108 U.S. men and women free of cardiovascular disease and cancer at baseline, followed prospectively for 5,517,225 person-years.

Exposure

Higher lignan intake (total lignans, matairesinol, secoisolariciresinol, pinoresinol, and lariciresinol) assessed via food frequency questionnaire every 2-4 years.

Comparator

Lower lignan intake (comparing extreme quintiles).

Outcome

Coronary heart disease (CHD), including non-fatal MI and fatal CHD.hard clinical

Main Result

Hazard Ratio: 0.85 (95% CI 0.79–0.92)

p-value: p=≤0.003

Increased long-term dietary intake of lignans is associated with a significantly lower risk of coronary heart disease, with potential synergistic benefits when combined with higher fiber intake.

Cite This Study

Hu et al. (2021) conducted a cohort in Coronary Heart Disease (n=214,108). Lignan intake vs. Lowest quintile of intake was evaluated on Coronary heart disease (CHD) (HR 0.85, 95% CI 0.79-0.92, p=≤0.003). Comparing extreme quintiles, higher total lignan intake was associated with a lower risk of coronary heart disease (HR 0.85; 95% CI 0.79-0.92; P≤0.003).

synapsesocial.com/papers/6a7b91c1a8f5aeb26c25a32d https://doi.org/10.1016/j.jacc.2021.05.049

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Implication

Increased long-term dietary intake of lignans is associated with a significantly lower risk of coronary heart disease, with potential synergistic benefits when combined with higher fiber intake.

Lignan Intake and Risk of Coronary Heart Disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Lignan Intake and Risk of Coronary Heart Disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider