Key result
Guideline-directed medical therapy for heart failure led to significant myocardial recovery, improving LVEF from 23% to 47% and resolving left ventricular thrombus over 5 months in a patient with late-onset anthracycline-induced cardiotoxicity.
Why the study?
Left ventricular dysfunction is a common and serious complication of cancer treatment, and anthracycline-induced cardiotoxicity may manifest after several years.
Case Report (n=1)
No
Early detection and guideline-directed medical therapy can lead to functional recovery and thrombus resolution in late-onset anthracycline-induced cardiotoxicity.
May support GDMT for recovery in select late-onset anthracycline cases; leaves open generalizability and prospective validation.
BACKGROUND: Left ventricular (LV) dysfunction is a common and serious complication from cancer treatment. One of the common regimens that can cause cardiotoxicity is anthracycline, and anthracycline-induced cardiotoxicity may manifest after several years. CASE SUMMARY: A 32-year-old woman presented with heart failure syndrome late after chemotherapy administration for breast cancer therapy. Several months after chemotherapy completion, patient presented with overt LV dysfunction. The guideline-directed medical treatment was initiated. Patient demonstrated gradual recovery and progressive improvement of myocardial systolic performance with LV thrombus resolution after 5-month evaluation. DISCUSSION: The recognition of cancer therapy-related cardiac dysfunction (CTRCD) is important since early detection and treatment with heart failure treatment provide a good functional recovery and long-term prognosis. The clinical application of longitudinal strain and myocardial work echocardiography in CTRCD cases for therapeutic response tracking and prognostication purposes is recommended. TAKE-HOME MESSAGE: Long-term postchemotherapy echocardiography evaluation especially in high-risk CTRCD criteria is of utmost importance due to the possibility of late-onset CTRCD.
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Hendiperdana et al. (2025) conducted a case report in Late-Onset Anthracycline-Induced Cardiotoxicity (n=1). Guideline-directed medical therapy for HFrEF was evaluated on Myocardial recovery (LVEF and GLS). Guideline-directed medical therapy for heart failure led to significant myocardial recovery, improving LVEF from 23% to 47% and resolving left ventricular thrombus over 5 months in a patient with late-onset anthracycline-induced cardiotoxicity.
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