Key result
Diet-induced obesity and insulin resistance are strongly associated with an increased risk for myocardial infarction, stroke, and vascular disease.
Supports intensified CVD risk management in obese insulin-resistant patients; leaves open causal mechanisms and intervention effects.
INSULIN RESISTANCE OCCURS frequently in people who are over-weight or obese. Elucidating the mechanisms responsible for insulin resistance and defining its physiological consequences are highly relevant to understanding human disease. Impaired insulin sensitivity in skeletal muscle and liver are directly responsible for the development of type 2 diabetes (15). Al-though insulin resistance in other organs does not constitute a disease per se, emerging evidence suggests that it plays a role in the pathogenesis of vascular disease and heart failure. Epidemiological studies have established a strong association between insulin resistance and an increased risk for myocardial infarction (6) and stroke (7). In part, the susceptibility to vascular disease reflects the high prevalence of hypertension and dyslipidemia, as well as alterations in adipocytokines, leading to vascular inflammation in insulin-resistant patients
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Lawrence H. Young (2009) studied Insulin resistance and obesity. Diet-induced obesity was evaluated. Diet-induced obesity and insulin resistance are strongly associated with an increased risk for myocardial infarction, stroke, and vascular disease.
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