Myocardial insulin resistance mechanisms merit targeted study in diabetic cardiomyopathy; leaves open whether modulating them improves clinical outcomes.
Key Points
This review aims to explore the mechanisms that connect insulin resistance to the development of cardiovascular disease.
Discussion of metabolic alterations induced by insulin resistance
Review of the lipid triad related to cardiovascular implications
Exploration of potential therapies targeting insulin resistance
Insulin resistance leads to chronic hyperglycemia, triggering oxidative stress and inflammatory responses.
Development of dyslipidemia characterized by elevated triglycerides, decreased HDL, and small dense LDL particles.
Insulin resistance alters myocardial substrate delivery and metabolism, contributing to atherosclerosis.