Key result
Combining breathing rate with signal amplitude and ARIMA coefficients improved the detection of exercise periods in COPD patients, achieving an AUC of 0.848 compared to 0.741 for breathing rate alone.
Why the study?
Monitoring breathing rate variation for early identification of acute COPD exacerbations has yielded unsatisfactory sensitivity or specificity, prompting the search for features that better describe respiratory pattern changes during short-term load-capacity-drive adjustments.
Does combining breathing features (amplitude, ARIMA, Fourier) improve the detection of breathing changes (rest vs effort) compared to breathing rate alone in healthy subjects and COPD patients?
Observational (n=28)
No
Does combining breathing features (amplitude, ARIMA, Fourier) improve the detection of breathing changes (rest vs effort) compared to breathing rate alone in healthy subjects and COPD patients?
Effect estimate: AUC 0.848 (95% CI 0.829-0.867)
Combining breathing rate with signal amplitude, ARIMA coefficients, or Fourier coefficients significantly improves the detection of respiratory pattern changes compared to using breathing rate alone.
Breathing features may aid COPD exacerbation monitoring; leaves open prospective validation before clinical use.
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is one of the top 10 causes of death worldwide, representing a major public health problem. Researchers have been looking for new technologies and methods for patient monitoring with the intention of an early identification of acute exacerbation events. Many of these works have been focusing in breathing rate variation, while achieving unsatisfactory sensitivity and/or specificity. This study aims to identify breathing features that better describe respiratory pattern changes in a short-term adjustment of the load-capacity-drive balance, using exercising data. RESULTS: Under any tested circumstances, breathing rate alone leads to poor capability of classifying rest and effort periods. The best performances were achieved when using Fourier coefficients or when combining breathing rate with the signal amplitude and/or ARIMA coefficients. CONCLUSIONS: Breathing rate alone is a quite poor feature in terms of prediction of breathing change and the addition of any of the other proposed features improves the classification power. Thus, the combination of features may be considered for enhancing exacerbation prediction methods based in the breathing signal. TRIAL REGISTRATION: ClinicalTrials NCT03753386. Registered 27 November 2018, https://clinicaltrials.gov/show/NCT03753386.
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Pegoraro et al. (2021) conducted an observational in Chronic Obstructive Pulmonary Disease (COPD) (n=28). Machine-learning models combining breathing rate with signal amplitude and ARIMA coefficients vs. Breathing rate alone was evaluated on Detection of exercise periods (classification of rest vs effort) in COPD patients using supervised classification (AUC 0.848, 95% CI 0.829-0.867). Combining breathing rate with signal amplitude and ARIMA coefficients improved the detection of exercise periods in COPD patients, achieving an AUC of 0.848 compared to 0.741 for breathing rate alone.
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