What question did this study set out to answer?

To review the epigenetic role of histone deacetylases and examine how their inhibitors suppress tumor growth across diverse cellular pathways.

October 23, 2012Molecular OncologyOpen Access

HDAC inhibitor‐based therapies: Can we interpret the code?

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Authors

MNMaria I. NewRutgers, The State University of New Jersey HOHeidi OlzschaLuther University NTNicholas B. La ThangueNortheast Catholic College

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Implication

Review reveals multi-targeted antitumor mechanisms of histone deacetylase inhibitors in lymphoma, highlighting the need to decipher molecular pathways for broader cancer treatment.

Key Points

To review the epigenetic role of histone deacetylases and examine how their inhibitors suppress tumor growth across diverse cellular pathways.
Reviewed chromatin remodeling and gene expression regulation driven by histone and non-histone acetylation.
Assessed preclinical cellular responses and clinical trials of approved and emerging histone deacetylase inhibitors.
Histone deacetylase inhibitors induce tumor cell apoptosis, cell-cycle arrest, differentiation, anti-angiogenesis, and autophagy.
Vorinostat and romidepsin demonstrate clinical efficacy and regulatory approval in cutaneous T-cell lymphoma.
Incomplete delineation of downstream molecular pathways continues to restrict the application of these therapies in other malignancies.

Cite This Study

New et al. (2012) studied this question.

synapsesocial.com/papers/6a7ba95124f98b6d3fc28c98 https://doi.org/10.1016/j.molonc.2012.09.003

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Implication

Review reveals multi-targeted antitumor mechanisms of histone deacetylase inhibitors in lymphoma, highlighting the need to decipher molecular pathways for broader cancer treatment.

HDAC inhibitor‐based therapies: Can we interpret the code?

Discussion

Member takes

Implication

Key Points

Cite This Study

HDAC inhibitor‐based therapies: Can we interpret the code?

Discussion

Member takes

Implication

Key Points

Cite This Study

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