Key result
A computational model incorporating pressure-induced intima compression and increased endothelial leaky junctions successfully reproduced experimental observations of increased LDL concentration in the arterial wall under hypertension.
A computational model incorporating pressure-induced intima compression and leaky junctions accurately reproduces experimental observations of increased LDL transport into the arterial wall during hypertension.
The influence of hypertension on low-density lipoproteins intake into the arterial wall is an important factor for understanding mechanisms of atherosclerosis. It has been experimentally observed that the increased pressure leads to the higher level of the LDL inside the wall. In this paper we attempt to construct a model of the LDL transport which reproduces quantitatively experimental outcomes. We supplement the well known four-layer arterial wall model to include two pressure induced effects: the compression of the intima tissue and the increase of the fraction of leaky junctions. We demonstrate that such model can reach the very good agreement with experimental data.
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Jesionek et al. (2016) studied Hypertension and Atherosclerosis. Hypertension (elevated transmural pressure) vs. Physiological pressure (70 mmHg) was evaluated on LDL concentration in the arterial wall. A computational model incorporating pressure-induced intima compression and increased endothelial leaky junctions successfully reproduced experimental observations of increased LDL concentration in the arterial wall under hypertension.
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