Key result
Functional genomic tools have revealed that RNA binding protein complexes support post-transcriptional RNA operons and interconnected regulatory networks in Trypanosoma cruzi.
This review highlights the importance of post-transcriptional regulation and RNA granules in the gene expression of Trypanosoma cruzi.
: The regulation of gene expression in trypanosomatids is predominantly post-transcriptional. Polycistronic transcripts are processed by the addition of a common 5’-spliced leader and polyadenylation. However, the processed mRNAs are not necessarily functionally related, suggesting the existence of mechanisms for the degradation or storage of untranslatable mRNAs. Determination of the TriTryps (Leishmania major, Trypanosoma brucei and Trypanosoma cruzi) genome sequences has allowed the identification of genes encoding potential regulatory proteins. This review discusses some of the mechanisms and regulatory elements involved in cytoplasmic gene expression regulation in Trypanosoma cruzi . We also discuss how functional genomic tools have contributed toward determining the role played by RNA binding protein complexes, supporting the concept of “post-transcriptional RNA operons” or “RNA regulons”. This suggests the existence of interconnected regulatory networks in the parasite, in which RNA granules act as protagonists in cytoplasmic mRNA metabolism.
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Ávila et al. (2010) conducted a review in Trypanosoma cruzi gene expression regulation. Functional genomic tools have revealed that RNA binding protein complexes support post-transcriptional RNA operons and interconnected regulatory networks in Trypanosoma cruzi.
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