Key result
Compliance with physical activity recommendations was independently associated with a beneficial hemodynamic profile, but this association was strongly moderated by age, showing lower blood pressure in younger subjects and lower waveform-derived indexes in older adults.
Why the study?
Few studies have comprehensively analyzed the association between compliance with physical activity recommendations and comprehensive cardiovascular properties across arterial territories, or how growth and aging moderate this relationship.
Does compliance with physical activity recommendations improve hemodynamic, structural, and functional arterial status in subjects aged 3-90 years?
Cross-Sectional (n=3,619)
Does compliance with physical activity recommendations improve hemodynamic, structural, and functional arterial status in subjects aged 3-90 years?
The cardiovascular benefits of physical activity are age-dependent, manifesting as lower blood pressure in younger individuals and improved hemodynamic indices in older adults.
Age moderates CPARs-arterial property links in this cross-sectional cohort; leaves open prospective confirmation of age-specific effects.
Background: Compliance with physical activity recommendations (CPARs) is associated with better health indicators. However, there are only few studies to date that have comprehensively analyzed the association between CPARs and cardiovascular status "as a whole" (e.g., analyzing hemodynamic, structural, and functional properties, and different arterial territories). The relationship between CPARs and cardiovascular properties could be strongly influenced by the growth and aging process. Aim: The goal of the study is to investigate the association between CPAR and cardiovascular properties by placing special emphasis on: (i) identifying if there is an independent association, (ii) if the association is "moderated" by age, and (iii) to what extent the association depends on the arterial parameter (hemodynamic vs. structural vs. functional) and/or the arterial segment (e.g., central vs. peripheral; elastic vs. transitional vs. muscular arteries). Methods: Age interaction) were obtained, and Johnson-Neyman technique was used to produce regions of significance. Results: The independent association between CPARs and cardiovascular characteristics were strongly moderated by age. The moderation was observed on a wide range of age but particularly notorious on the extremes of life. Certain arterial characteristics demonstrated opposite effects in relation to CPAR status depending on the range of age considered. The association between CPAR and cardiovascular characteristics was independent of CRFs and moderated by age. In subjects younger than 45-55 years, CPAR status was associated with lower central and peripheral blood pressure (i.e., the younger the subject, the higher the reduction). During adult life, as age increases in the subjects, CPARs was associated with a beneficial hemodynamic profile, which is not related with variations in pressure but strongly related with lower levels of waveform-derived indexes and ventricular afterload determinants. Conclusions: The independent associations between CPARs and arterial properties were strongly moderated by age. Data provided by blood pressure levels and waveform-derived indexes would be enough to evaluate the independent association between CPARs and the vascular system in the general population.
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Zócalo et al. (2022) conducted a cross-sectional in General population (n=3,619). Compliance with international physical activity recommendations vs. Non-compliance with physical activity recommendations was evaluated on Association between compliance with physical activity recommendations and cardiovascular characteristics moderated by age. Compliance with physical activity recommendations was independently associated with a beneficial hemodynamic profile, but this association was strongly moderated by age, showing lower blood pressure in younger subjects and lower waveform-derived indexes in older adults.
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