Key result
Higher systolic BP variability linked to ~21% higher odds of postprandial hypotension per SD in diabetes.
Why the study?
Postprandial hypotension is prevalent but often overlooked in type 2 diabetes mellitus, and its relationship with comprehensive 24-hour hemodynamic profiles remains poorly defined.
Is postprandial hypotension associated with increased blood pressure variability and abnormal circadian patterns in patients with type 2 diabetes mellitus?
Cross-Sectional (n=67)
No
Is postprandial hypotension associated with increased blood pressure variability and abnormal circadian patterns in patients with type 2 diabetes mellitus?
Odds Ratio: 1.211 (95% CI 1.043–1.406)
p-value: p=0.012
Postprandial hypotension is prevalent in over 40% of patients with stable type 2 diabetes and acts as an independent marker of increased blood pressure variability, suggesting a phenotype of broader hemodynamic and autonomic instability.
May warrant BP variability assessment in type 2 diabetes; extends observational links to postprandial hypotension but leaves causal effects open.
Background: Postprandial hypotension (PPH), which is associated with adverse cardiovascular outcomes, is a prevalent but often overlooked in individuals with type 2 diabetes mellitus (T2DM). In addition, its relationship with comprehensive 24-hour hemodynamic profiles remains poorly defined. We aimed to assess the prevalence and characteristics of PPH in patients with T2DM and to determine its association with systolic blood pressure (SBP) variability and circadian blood pressure (BP) patterns. Methods: We prospectively enrolled T2DM patients with stable glycemic control. PPH was defined as a post-meal SBP fall of ≥ 20 mmHg or a drop to < 90 mmHg within 2 hours after a meal. Hemodynamic patterns, including SBP variability (standard deviation) and circadian rhythms, were analyzed via 24-hour ambulatory BP monitoring. Results: = 0.012). Conclusions: In our cohort, PPH was found in 41.8% of patients with T2DM and was independently associated with increased SBP variability. These results suggest that BP variability could be a valuable marker for identifying individuals at higher risk for postprandial hemodynamic instability.
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Lee et al. (2026) conducted a cross-sectional in Type 2 diabetes mellitus (n=67). 24-hour systolic blood pressure variability was evaluated on Presence of postprandial hypotension (OR 1.211, 95% CI 1.043-1.406, p=0.012). In patients with type 2 diabetes, a 1-SD increase in 24-hour systolic blood pressure variability was independently associated with the presence of postprandial hypotension (OR 1.211).
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