September 28, 1992FEBS LettersOpen Access

Regulatory light‐chain Cys‐55 sites on the two heads of myosin can come within 2Å of each other

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Population

Scallop hybrid myosin in solution

Design

Preclinical

Authors

SBSusanne M. BowerDrexel University YWYulai Wang PCPeter D. ChantlerRoyal Veterinary College

Discussion

Member takes

Implication

No immediate clinical implications; leaves open relevance of myosin head proximity to human cardiac regulation.

Structured PICO

Population

Scallop hybrid myosin in solution

Intervention

5,5'-dithiobis (2-nitrobenzoic acid) (di-thiol reagent)

Outcome

Disulfide bond formation between Mercenaria regulatory light-chain Cys-55 sites on either head of scallop hybrid myosinsurrogate

Myosin heads in solution demonstrate considerable mutual freedom of movement, allowing regulatory light-chain Cys-55 sites on opposite heads to come within 2Å of each other.

Cite This Study

Bower et al. (1992) studied this question.

synapsesocial.com/papers/6a7bc1df01db1a7270ed2657 https://doi.org/10.1016/0014-5793(92)81313-b

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Ask AI

Bookmark

Regulatory light‐chain Cys‐55 sites on the two heads of myosin can come within 2Å of each other

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulatory light‐chain Cys‐55 sites on the two heads of myosin can come within 2Å of each other

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider