What question did this study set out to answer?

Compare the diagnostic accuracy of blood enzyme markers, clinical evaluations, and radiographs against radionuclide bone scans for detecting prostate cancer bone metastases.

November 1, 1976Radiology

Comparison of Enzyme, Clinical, Radiographic, and Radionuclide Methods of Detecting Bone Metastases from Carcinoma of the Prostate

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Compare the diagnostic accuracy of blood enzyme markers, clinical evaluations, and radiographs against radionuclide bone scans for detecting prostate cancer bone metastases.
Evaluated 219 patients with prostatic adenocarcinoma classified by radionuclide bone scan positivity.
Reviewed serum acid phosphatase and alkaline phosphatase levels, clinical evaluations of bone pain, and radiographic imaging.
Among patients with confirmed metastases, 43% lacked bone pain, 39% had normal acid phosphatase, 23% had normal alkaline phosphatase, 19% had normal levels of both enzymes, and 15% had normal enzymes without bone pain.
Of patients with normal enzyme levels and clinically unsuspected metastases, 24% had positive bone scans, and 62% of these scan-positive patients had normal radiographs.

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Implication

Comparative study reveals high rates of normal enzymes and absent pain in prostate cancer bone metastases, highlighting the superiority of radionuclide bone scans.

Cite This Study

Schaffer et al. (1976) studied this question.

synapsesocial.com/papers/6a7bc546073f483584df8f49 https://doi.org/10.1148/121.2.431

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Implication

Comparative study reveals high rates of normal enzymes and absent pain in prostate cancer bone metastases, highlighting the superiority of radionuclide bone scans.

Comparison of Enzyme, Clinical, Radiographic, and Radionuclide Methods of Detecting Bone Metastases from Carcinoma of the Prostate

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Discussion

Implication

Cite This Study

Comparison of Enzyme, Clinical, Radiographic, and Radionuclide Methods of Detecting Bone Metastases from Carcinoma of the Prostate

Key Points

Discussion

Implication

Cite This Study

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