Alzheimer?s Disease in Senile Dementia: Loss of Neurones in the Basal Forebrain. Whitehouse, P., Price, D., Struble, R., Clarke, A., Coyle, J. and Delong, M.Science (1982), 215, 1237-1239

6 Control 55.8+3.4 5.3+0.1 5.9+0.9344.6+64.6The ratings, density and counts were signi®cantly dierence from controls at p `0.004.The authors conclude that their demonstration of selective degeneration of nbM neurones provides the ®rst example of a transmitter-speci®c cell population loss and represents, as indeed it did, a signi®cant step to the understanding of the disorder.