Key result
Platinum-based chemotherapy was associated with increased arterial stiffness and decreased flow-mediated dilatation, suggesting it directly induces vascular endothelial dysfunction.
Why the study?
Does platinum-based adjuvant chemotherapy increase arterial stiffness and vascular endothelial dysfunction in women undergoing surgical treatment for gynecological malignancies?
Population
47 women with gynecological malignancies who underwent surgical treatment between 2007 and 2009. The study…
Comparison
Platinum-based adjuvant chemotherapy vs Surgical treatment without platinum-based…
Design
Cohort
Follow-up
12 months after treatment
Authors
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May elevate long-term CV risk in survivors; leaves open whether platinum regimens warrant vascular monitoring or alternatives.
Cohort (n=47)
Does platinum-based adjuvant chemotherapy increase arterial stiffness and vascular endothelial dysfunction in women undergoing surgical treatment for gynecological malignancies?
Platinum-based chemotherapy induces vascular endothelial dysfunction and increases arterial stiffness, suggesting it is a risk factor for atherosclerosis in gynecologic cancer survivors.
Sekijima et al. (2010) conducted a cohort in Gynecological malignancies (ovarian and endometrial cancers) (n=47). Platinum-based adjuvant chemotherapy vs. Surgical treatment without platinum-based chemotherapy was evaluated on Arterial stiffness (baPWV) and flow-mediated dilatation. Platinum-based chemotherapy was associated with increased arterial stiffness and decreased flow-mediated dilatation, suggesting it directly induces vascular endothelial dysfunction.
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