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January 19, 2006Journal of Clinical Oncology350 citationsOpen Access

Long-Term Risk of Cardiovascular Disease in 5-Year Survivors of Testicular Cancer

ABAlexandra W. van den Belt‐DuseboutJNJanine NuverRWRonald de Wit

Key Points

  • To assess the long-term risk of cardiovascular disease and myocardial infarction among 5-year survivors of testicular cancer.
  • Evaluated cardiovascular disease and myocardial infarction outcomes among long-term, 5-year testicular cancer survivors.
  • Examined the influence of treatment modalities—including mediastinal radiotherapy, PVB chemotherapy, BEP chemotherapy—and lifestyle factors such as smoking.
  • Nonseminomatous testicular cancer survivors experience a moderately elevated risk of myocardial infarction at young ages.
  • Excess cardiovascular disease risk is specifically linked to treatment with mediastinal radiotherapy, PVB chemotherapy regimens, and recent smoking.

Abstract

Nonseminomatous TC survivors experience a moderately increased MI risk at young ages. Physicians should be aware of excess CVD risk associated with mediastinal radiotherapy, PVB CT, and recent smoking. Intervention in modifiable cardiovascular risk factors is especially important in TC survivors. Whether BEP treatment increases CVD risk should be evaluated after more prolonged follow-up.

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Cite This Study

Belt‐Dusebout et al. (2006) studied this question.

synapsesocial.com/papers/69d56c0d75589c71d767cafbhttps://doi.org/10.1200/jco.2005.02.7193
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