An effective strategy to synthesize spirocyclic compounds, [imidazole-4,1′-indene], has been efficaciously developed relied on Rh(III)-catalyzed [3 + 2] spirocyclization of 2 H -imidazoles and 1,3-diynes with excellent chemselectivity and regioselectivity. This protocol shows a straightforward way to construct the versatile spirocyclic compounds with wide functional group compatibility, high atom economy, and diverse functionalization of products.
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Luo et al. (2020) studied this question.
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