What is the clinical evidence from this study?

Study design: Other. Population: Healthy (n=23). Intervention: Mixed meal and forearm exercise vs. Baseline. Primary outcome: Forearm muscle microvascular blood volume (p=<0.01).

What question did this study set out to answer?

To determine whether consuming a mixed meal or performing light exercise stimulates skeletal muscle capillary recruitment to facilitate nutrient exchange in healthy humans.

May 8, 2006AJP Endocrinology and Metabolism

Mixed meal and light exercise each recruit muscle capillaries in healthy humans

Q: What are the key findings of this study?

A 480-kcal mixed meal and light exercise (25% max) each significantly increased muscle microvascular volume (P<0.01) in healthy humans.

Q: What question did this study set out to answer?

To determine whether consuming a mixed meal or performing light exercise stimulates skeletal muscle capillary recruitment to facilitate nutrient exchange in healthy humans.

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Key result

A 480-kcal mixed meal and light exercise (25% max) each significantly increased muscle microvascular volume (P<0.01) in healthy humans.

Why the study?

Do mixed meals and light exercise increase muscle microvascular volume in healthy humans?

Population

18 healthy volunteers for the meal study, and 5 healthy adults for the exercise study.

Comparison

480-kcal liquid mixed meal; and light, moderate… vs Baseline (before meal or exercise)

Design

Other

Follow-up

Up to 60 minutes

Authors

MVMichelle A. VincentUniversity of Virginia LCLucy H. ClerkUniversity of Virginia JLJonathan R. LindnerUniversity of Virginia Health System

Discussion

Member takes

Implication

May enhance postprandial nutrient exchange via microvascular recruitment; leaves open relevance in insulin-resistant or diseased states.

Key Points

To determine whether consuming a mixed meal or performing light exercise stimulates skeletal muscle capillary recruitment to facilitate nutrient exchange in healthy humans.
Measured plasma glucose, insulin, brachial artery flow, and forearm microvascular blood volume before and after a 480-kcal liquid mixed meal in 18 healthy volunteers (9 M, 9 F).
Assessed brachial artery flow and microvascular volume during forearm contractions at 25% (light), 50% (moderate), and 80% (heavy) of maximal grip strength performed every 20 seconds in 5 healthy adults (4 M, 1 F).
Post-meal glucose peaked at ~7 mM and insulin at ~270 pM by 30 min, followed by significant increases at 60 min in brachial artery blood flow (P < 0.05) and microvascular volume (P < 0.01), without changes in microvascular flow velocity.
Light exercise (25% grip) induced a threefold increase in microvascular volume (P < 0.01) without altering total flow or flow velocity, whereas 80% grip increased both microvascular volume and flow velocity (P < 0.05 each).

Structured PICO

Do mixed meals and light exercise increase muscle microvascular volume in healthy humans?

Population

23 healthy volunteers evaluated for muscle capillary recruitment following a 480-kcal mixed meal or varying intensities of forearm exercise.

Intervention

480-kcal liquid mixed meal; and light (25% max), moderate (50%), and heavy (80%) forearm contraction every 20 seconds.

Comparator

Baseline (before meal or exercise)

Outcome

Brachial artery flow and forearm muscle microvascular blood volumesurrogate

Main Result

p-value: p=<0.01

Both simple meals and light exercise significantly increase muscle microvascular volume, expanding the endothelial surface for nutrient exchange in healthy humans.

Cite This Study

Vincent et al. (2006) studied Healthy (n=23). Mixed meal and forearm exercise vs. Baseline was evaluated on Forearm muscle microvascular blood volume (p=<0.01). A 480-kcal mixed meal and light exercise (25% max) each significantly increased muscle microvascular volume (P<0.01) in healthy humans.

synapsesocial.com/papers/6a7bd4560449e558d7c2a8cf https://doi.org/10.1152/ajpendo.00497.2005

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Mixed meal and light exercise each recruit muscle capillaries in healthy humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Mixed meal and light exercise each recruit muscle capillaries in healthy humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider