Key result
In vivo endothelial cells rapidly take up and concentrate insulin, and IGF-IR, like IR, may mediate insulin transit through endothelial cells in a process involving caveolae.
Population
Rat skeletal muscle in vivo and cultured bovine aortic endothelial cells (bAECs)
Design
Preclinical
Follow-up
60 min
Authors
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Does not yet support clinical targeting of endothelial IGF-IR; extends preclinical understanding of insulin transit.
Vascular endothelial cells mediate insulin transport into skeletal muscle via insulin receptors and IGF-I receptors in a process involving caveolae.
Wang et al. (2006) studied this question. FITC-labeled insulin infusion was evaluated on Insulin transport and distribution in skeletal muscle vasculature and cultured bAECs. In vivo endothelial cells rapidly take up and concentrate insulin, and IGF-IR, like IR, may mediate insulin transit through endothelial cells in a process involving caveolae.
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