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May 1, 2002Journal of NeuroscienceOpen Access

Depressor and Tachypneic Responses to Chemical Stimulation of the Ventral Respiratory Group Are Reduced by Ablation of Neurokinin-1 Receptor-Expressing Neurons

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Why the study?

Does ablation of NK1R-expressing neurons in the RVLM alter cardiorespiratory responses to chemical stimulation of the VRG in rats?

Population

Rats (intact and with selective unilateral ablation of RVLM NK1R-immunoreactive cells)

Comparison

Selective unilateral ablation of RVLM… vs Free SAP injection or untreated contralateral side

Design

Preclinical

Authors

HWHong WangBeijing University of Chinese MedicineTGTeresa P. GermansonUniversity of Virginia Health SystemPGPatrice G. GuyenetUniversity of North Carolina at Chapel Hill

Discussion

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Implication

NK1R ablation effects in rats do not support clinical use; leaves open translation to human cardiorespiratory control.

Structured PICO

Does ablation of NK1R-expressing neurons in the RVLM alter cardiorespiratory responses to chemical stimulation of the VRG in rats?

P
Population
Rats (intact and with selective unilateral ablation of RVLM NK1R-immunoreactive cells)
I
Intervention
Selective unilateral ablation of RVLM NK1R-immunoreactive cells using saporin (SAP) conjugated with a selective NK1R agonist [Sar9, Met(O2)11]-substance P (SSP), followed by injection of dl-homocysteic acid (DLH) into the ventral respiratory group (VRG)
C
Comparator
Free SAP injection (control) or untreated contralateral side
O
Outcome
Cardiorespiratory responses (phrenic nerve discharge [PND] and arterial pressure [AP])surrogate

NK1R-expressing cells in the rostral ventrolateral medulla play a role in controlling both respiratory rhythm and blood pressure responses to chemical stimulation.

Cite This Study

Wang et al. (2002) studied this question.

synapsesocial.com/papers/6a8154dc267334e2baf09301https://doi.org/10.1523/jneurosci.22-09-03755.2002

Topics

Hypertension managementThymosin beta-4
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