Population
Hepatitis C virus recombinant RF1_2k/1b (N687) and non-recombinant 1b strain N589
Design
Preclinical
Authors
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Hypothesis-generating for HCV recombination; leaves open validation in human infections and therapeutic relevance.
The study proposes a mechanism for the formation of a recombinant hepatitis C virus strain via homologous recombination during minus-strand synthesis.
Kalinina et al. (2004) studied this question.
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