October 16, 2007Annals of Internal Medicine
Effect of Low-Dose Aspirin on the Occurrence of Venous Thromboembolism
Why the study?
Does long-term low-dose aspirin prevent venous thromboembolism in initially healthy women?
Population
39,876 initially healthy U.S. female health care professionals age 45 years or older
Comparison
Aspirin 100 mg on alternate days vs Placebo on alternate days
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
10-year
Authors
Discussion
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Implication
Low-dose aspirin is not indicated for VTE prevention in healthy women; confirms no benefit in this primary prevention RCT.
Structured PICO
Does long-term low-dose aspirin prevent venous thromboembolism in initially healthy women?
P
Population
39,876 initially healthy U.S. female health care professionals age 45 years or older
I
Intervention
Aspirin 100 mg on alternate days
C
Comparator
Placebo on alternate days
O
Outcome
Documented venous thromboembolism (deep venous thrombosis or pulmonary embolism)hard clinical
Long-term, low-dose alternate-day aspirin does not significantly reduce the risk of venous thromboembolism in initially healthy women.
Limitations
- Venous thromboembolism was a secondary end point in the Women's Health Study.
Cite This Study
Glynn et al. (2007) studied this question.