Why the study?
Does the addition of aspirin or triflusal to unfractionated heparin reduce the risk of pulmonary embolism and deep vein thrombosis in patients undergoing hip surgery?
Population
459 consecutive patients operated on because of hip fracture (n=265) or elective hip replacement (n=194)
Comparison
Aspirin or Triflusal added to unfractionated… vs Matching placebo added to unfractionated heparin
Design
RCT, randomized, double-blind
Follow-up
8-9 days post-surgery
Authors
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No benefit from adding aspirin or triflusal to heparin for VTE prevention in hip surgery; identifies low pre-operative platelet count as postoperative PE risk factor.
Does the addition of aspirin or triflusal to unfractionated heparin reduce the risk of pulmonary embolism and deep vein thrombosis in patients undergoing hip surgery?
Adding aspirin or triflusal to unfractionated heparin did not significantly reduce VTE in hip surgery patients, but lower pre-operative platelet counts were identified as a significant predictor of postoperative pulmonary embolism.
Monréal et al. (1995) studied this question.
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