August 1, 1999AJP Endocrinology and Metabolism

Monoclonal antibodies to growth hormone (GH) prolong liver GH binding and GH-induced IGF-I/IGFBP-3 synthesis

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Structured PICO

Population

Hypophysectomized rats

Intervention

Single injection of bovine growth hormone (bGH) complexed with an anti-bGH monoclonal antibody

Comparator

Single injection of bovine growth hormone (bGH) alone

Outcome

Serum insulin-like growth factor I (IGF-I) concentrations, liver IGF-I mRNA, serum IGFBP-3, liver IGFBP-3 mRNA, and GH receptor occupancy over 48 hourssurrogate

Monoclonal antibodies against growth hormone amplify and prolong its effects by sustaining GH binding to liver receptors, leading to increased IGF-I and IGFBP-3 synthesis.

Discussion

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Implication

MAb-GH complexes prolong IGF-I elevation in animals; hypothesis-generating for GH potentiation strategies pending human trials.

Cite This Study

Beauloye et al. (1999) studied this question.

synapsesocial.com/papers/6a7be105eac460320975d4ef https://doi.org/10.1152/ajpendo.1999.277.2.e308

View Full Paper

Ask AI

Bookmark

Monoclonal antibodies to growth hormone (GH) prolong liver GH binding and GH-induced IGF-I/IGFBP-3 synthesis

Structured PICO

Discussion

Implication

Cite This Study

Monoclonal antibodies to growth hormone (GH) prolong liver GH binding and GH-induced IGF-I/IGFBP-3 synthesis

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider