Key result
Delaying surgery in hip fracture patients taking DOACs was not associated with a reduction in perioperative bleeding (regression coefficient -0.06 g/L/hour; 95% CI -0.32-0.20; p=0.64).
Why the study?
Does delaying surgery in patients taking DOACs who suffer a hip fracture reduce perioperative bleeding?
Population
125 patients who sustained a hip fracture, including those taking a direct oral anticoagulant at the time of…
Comparison
Operative treatment of hip fracture without… vs Matched group not taking a DOAC
Design
Case-control
Follow-up
30 days
Authors
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Immediate surgery without DOAC washout was not associated with excess bleeding; leaves open optimal timing pending prospective trials.
Case-Control (n=125)
No
Does delaying surgery in patients taking DOACs who suffer a hip fracture reduce perioperative bleeding?
Effect estimate: regression coefficient -0.06 g/L/hour (95% CI -0.32-0.20)
p-value: p=0.64
Delaying hip fracture surgery in patients taking DOACs does not appear to reduce perioperative bleeding or affect mortality.
Mullins et al. (2018) conducted a case-control in hip fracture (n=125). Delaying surgery (admission to operation interval) in patients taking DOACs vs. Shorter admission to operation interval / matched group not taking DOACs was evaluated on Perioperative drop in haemoglobin concentration (regression coefficient -0.06 g/L/hour, 95% CI -0.32-0.20, p=0.64). Delaying surgery in hip fracture patients taking DOACs was not associated with a reduction in perioperative bleeding (regression coefficient -0.06 g/L/hour; 95% CI -0.32-0.20; p=0.64).
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