Key result
Torasemide is an effective and safe loop diuretic for symptomatic heart failure, providing optimal pharmacokinetics and positive impacts on myocardial fibrosis.
Torasemide is highlighted as an optimal loop diuretic for symptomatic heart failure due to its favorable pharmacokinetic profile and additional pleiotropic effects.
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May favor sustained-release torasemide in symptomatic HF; hypothesis-generating and requires randomized confirmation before practice change.
Loop diuretics take the lead in the treatment of patients with symptomatic heart failure. Torasemide is the most effective and safe loop diuretic with the optimal pharmacokinetic profile, the additional properties associated with simultaneous blockade of the renin-angiotensin-aldosterone system and with the antiadrenergic effects of the drug, its positive impact on myocardial fibrosis and minimal severe potential negative effects. Sustained-release torasemide provides a more comfortable removal of excess liquid and does not deteriorate quality of life.
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Курлыкина et al. (2017) conducted a review in Symptomatic heart failure. Torasemide was evaluated. Torasemide is an effective and safe loop diuretic for symptomatic heart failure, providing optimal pharmacokinetics and positive impacts on myocardial fibrosis.
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