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January 1, 2025CrystEngComm

Solvent selection as a major determinant of chiral resolution outcomes: the BINOL–DACH case study

Joséphine de Meester Oleksii Shemchuk Laurent Collard Johan Wouters Koen Robeyns Tom Leyssens

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Key Points

The research aims to evaluate how different solvents influence chiral resolution processes involving BINOL and DACH.
Examined the effects of various solvents on chiral resolution outcomes.
Utilized a combination of BINOL and DACH chiral molecules in experiments.
Identified that solvent selection significantly affects the efficiency of chiral resolution.
Demonstrated specific solvent-molecule combinations that enhance resolution outcomes.

Implication

Demonstrates the impact of solvent choice on chiral resolution of BINOL and DACH compounds, suggesting optimization avenues.

Abstract

By studying the combination of two chiral molecules, we highlight the importance of solvent choice when developing chiral resolution processes.

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Cite This Study

Meester et al. (2025) studied this question.

synapsesocial.com/papers/6a7be4cba540d02696c2a9f6 https://doi.org/10.1039/d5ce00706b

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