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December 1, 2020Radiology Cardiothoracic ImagingOpen Access

Coronary Artery Calcium Scoring: New Insights into Clinical Interpretation—Lessons from the CAC Consortium

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Key result

Coronary artery calcium scoring effectively stratifies long-term cardiovascular risk across ethnicities, age groups, and sexes, with a CAC of 0 serving as a reliable negative risk factor.

Why the study?

This review aimed to demystify coronary artery calcium as a clinical decision-guiding tool and clarify who might benefit from its use in clinical practice.

Does coronary artery calcium (CAC) scoring improve cardiovascular risk stratification and event prediction compared to traditional risk scores?

Population

Patients from the CAC Consortium cohort

Design

Review of multicenter retrospective cohort studies

Follow-up

Long-term

Authors

SASiegfried AdelhoeferJohns Hopkins UniversitySUS.M. Iftekhar UddinRuhr University BochumAOAlbert D. OseiUniversity of Pittsburgh

Discussion

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Implication

CAC stratification of mortality risk across groups supports expanded investigation; should not yet change practice without prospective trials.

Structured PICO

Does coronary artery calcium (CAC) scoring improve cardiovascular risk stratification and event prediction compared to traditional risk scores?

P
Population
66,636 asymptomatic adults free of known cardiovascular disease at baseline who underwent coronary artery calcium testing for clinical risk stratification.
E
Exposure
Coronary artery calcium (CAC) scoring
C
Comparator
Other widely used risk scores
O
Outcome
Long-term, cause-specific mortality and cardiovascular disease (CVD) event predictionhard clinical

CAC scoring provides consistent cardiovascular risk stratification and may offer value beyond current guidelines, including in select young patients and those with a family history.

Limitations

  • Retrospective nature of the CAC Consortium cohort study

Cite This Study

Adelhoefer et al. (2020) conducted a review in Asymptomatic adults free of known cardiovascular disease (n=66,636). Coronary artery calcium (CAC) scoring vs. CAC of 0 or lower CAC scores was evaluated on Long-term cause-specific mortality (coronary heart disease, cardiovascular disease, and non-CVD mortality). Coronary artery calcium scoring effectively stratifies long-term cardiovascular risk across ethnicities, age groups, and sexes, with a CAC of 0 serving as a reliable negative risk factor.

synapsesocial.com/papers/6a7be632a540d02696c2aab7https://doi.org/10.1148/ryct.2020200281
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Also Consider

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