Why the study?
Does declining health-related quality of life at 6 months predict later major adverse cardiac and cerebrovascular events in patients after coronary artery bypass surgery?
Does declining health-related quality of life at 6 months predict later major adverse cardiac and cerebrovascular events in patients after coronary artery bypass surgery?
Declining health-related quality of life and function scores at 6 months after CABG independently predict subsequent major adverse cardiovascular events.
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May flag higher post-CABG MACCE risk via 6-month QoL scores; leaves open whether targeting QoL alters events.
PURPOSE: Health-related quality of life (HRQoL) measured on the EQ-5D (European quality of life-5 dimensions)-questionnaire has been shown to improve after coronary artery bypass grafting (CABG), this study investigated whether changes in HRQoL predict later morbidity. METHODS: Included were 404 consecutive patients undergoing isolated CABG between 2008 and 2010 who filled the EQ-5D-questionnaire at baseline and 6 months postoperatively. Records were reviewed for later major adverse cardiac and cerebrovascular events (MACCE) after 6 months. Follow-up was 38.6 months (10-58). RESULTS: Patients who suffered later MACCE more often had suffered an in-hospital postoperative stroke, had a longer in-hospital stay, had lower HRQoL scores at 6 months and deteriorated on several EQ-5D-subscales. Logistic regression showed 6 months visual analogue scale scores and declining function scores to be independent predictors of later MACCE. CONCLUSION: Deteriorating function and HRQoL-scores at 6 months as compared to baseline postoperatively predict later adverse cardiovascular events after CABG.
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Gunn et al. (2013) studied this question.
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