What question did this study set out to answer?

To evaluate circulating plasma levels of adiponectin and resistin in individuals with masked hypertension compared with matched healthy normotensive controls.

February 1, 2009Journal of Clinical HypertensionOpen Access

Masked Hypertension and Atherogenesis: The Impact on Adiponectin and Resistin Plasma Levels

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Why the study?

Are adiponectin and resistin plasma levels altered in patients with masked hypertension compared to normotensive individuals?

Population

130 healthy persons (60 men, 70 women), mean age 45+/-12 years, with clinic blood pressure <140/90 mm Hg.

Comparison

Masked hypertension vs Normal ABPM findings (normotensive)

Design

Cross-sectional

Authors

DPDimitris PapadopoulosLaiko General Hospital of Athens DPDespina PerreaNational and Kapodistrian University of Athens CTCostas ThomopoulosPreventive Cardiology

Discussion

Member takes

Implication

Association of masked hypertension with altered adipokine levels is hypothesis-generating; does not yet support changes in clinical management.

Key Points

To evaluate circulating plasma levels of adiponectin and resistin in individuals with masked hypertension compared with matched healthy normotensive controls.
Evaluated 130 participants (mean age 45±12 years; 60 men and 70 women) with normal clinic blood pressure (<140/90 mm Hg) matched for age, sex, body mass index, and cardiovascular risk factors.
Performed 24-hour ambulatory blood pressure monitoring (ABPM) to identify masked hypertension (daytime systolic ≥135 mm Hg or diastolic ≥85 mm Hg; n=24) versus normotension (n=106).
Quantified plasma concentrations of adiponectin and resistin across both groups using enzyme-linked immunosorbent assay (ELISA).
Plasma resistin concentrations were significantly higher in the masked hypertension group compared with normotensive controls (12±4 vs 6.8±3.6 ng/mL; P<.01).
Plasma adiponectin concentrations were significantly lower in individuals with masked hypertension than in normotensive controls (6±2.3 vs 11±2.7 μg/mL; P<.01).

Structured PICO

Are adiponectin and resistin plasma levels altered in patients with masked hypertension compared to normotensive individuals?

Population

130 healthy persons (60 men, 70 women), mean age 45+/-12 years, with clinic blood pressure <140/90 mm Hg.

Intervention

Masked hypertension (daytime systolic blood pressure >=135 mm Hg or daytime diastolic blood pressure >=85 mm Hg on 24-hour ABPM)

Comparator

Normal ABPM findings (normotensive)

Outcome

Adiponectin and resistin plasma levelssurrogate

Masked hypertension is associated with a pro-inflammatory and pro-atherogenic biomarker profile, characterized by lower adiponectin and higher resistin levels.

Cite This Study

Papadopoulos et al. (2009) studied this question.

synapsesocial.com/papers/6a7be7ae2305edf9bbed29cc https://doi.org/10.1111/j.1751-7176.2008.00070.x

Topics

Hypertension management

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Implication

Association of masked hypertension with altered adipokine levels is hypothesis-generating; does not yet support changes in clinical management.

Masked Hypertension and Atherogenesis: The Impact on Adiponectin and Resistin Plasma Levels

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Masked Hypertension and Atherogenesis: The Impact on Adiponectin and Resistin Plasma Levels

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider