Rabbit blood cells incubated in vitro with purified parainfluenza-5 virus (DA strain) released a rapidly acting pyrogen. Spleen and lymph node cells were inactive. The pyrogen resembled in behavior a pyrogen extracted from granulocytic exudates. Similar cells in the blood are believed to be activated by virus in vivo to produce the circulating endogenous pyrogen that mediates virus-induced fever.
No takes yet. Share an insight, caveat, or question.
Atkins et al. (1964) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: