Why the study?
Does an automated fluorescence-based PCR method improve the detection of Neisseria meningitidis compared to manual methods?
Does an automated fluorescence-based PCR method improve the detection of Neisseria meningitidis compared to manual methods?
An automated fluorescence-based PCR assay offers a sensitive, reproducible, and less labor-intensive alternative to manual methods for confirming meningococcal disease.
May streamline meningococcal PCR confirmation in labs; leaves open prospective clinical validation.
A fluorescence-based PCR method was developed, fully automated, and used to confirm infection with Neisseria meningitidis by detection of the meningococcus-specific ctrA gene. The method provided a highly sensitive, high-throughput assay that was reproducible and less labor-intensive than manual methods.
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Diggle et al. (2001) studied this question.
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