Why the study?
Does the MeningoFinder assay accurately detect six virus species causing central nervous system infections in clinical CSF samples compared to PCRs?
Does the MeningoFinder assay accurately detect six virus species causing central nervous system infections in clinical CSF samples compared to PCRs?
The MeningoFinder assay demonstrates high sensitivity and specificity for the simultaneous detection of six virus species in CSF samples compared to standard PCR.
May support multiplex CNS virus detection in CSF; leaves open routine adoption pending prospective validation.
A multiplex ligation-dependent probe amplification assay for simultaneous detection of six virus species was developed and tested on clinical cerebrospinal fluid (CSF) samples. The assay, termed MeningoFinder, showed an accordance of 97%, concordance of 96%, interlaboratory sensitivity of 90%, and interlaboratory specificity of 94% compared to PCRs.
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Wolffs et al. (2009) studied this question.
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