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Experimental demonstration of mitochondrial localization by neutral rhodol dyes suggests a novel mechanism.
Neutral rhodol-based red emitters are shown to efficiently localize in mitochondria, as demonstrated by confocal microscopy and co-localization studies. A simple model is proposed to explain the localization mechanism of neutral molecules. The model takes into account the strong coupling between the molecular dipole moment and the electric field of the inner mitochondrial membrane.
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Ferraboschi et al. (2024) studied this question.
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