Key result
Denture use was associated with an increased unadjusted risk of ischemic events after acute myocardial infarction, but this was not significant after multivariable adjustment (HR 1.19).
Why the study?
Given the link between oral diseases and cardiovascular disease and high stomatitis rates in denture wearers, it was unknown whether denture use is associated with poor clinical outcomes after acute myocardial infarction.
Does denture use increase the risk of ischemic and bleeding events in patients with acute myocardial infarction undergoing primary PCI?
Observational (n=1,046)
Yes
Does denture use increase the risk of ischemic and bleeding events in patients with acute myocardial infarction undergoing primary PCI?
Hazard Ratio: 1.19 (95% CI 0.85–1.67)
Absolute Event Rate: 19.1% vs 14.4%
p-value: p=0.31
Denture use in patients with acute myocardial infarction is associated with an increased risk of subsequent ischemic events, highlighting a potential link between oral health and cardiovascular outcomes.
Denture use was associated with higher post-MI ischemic risk but not bleeding; leaves open confounding versus causality in observational data.
Objective Oral diseases, including periodontitis and stomatitis, are highly prevalent worldwide and reportedly associated with the development of cardiovascular disease. Given the high rate of stomatitis in individuals wearing dentures, denture users may be at high risk of poor cardiovascular outcomes. We therefore investigated whether or not the use of dentures is associated with a poor clinical outcome in patients with acute myocardial infarction (MI). Methods This two-center retrospective observational study was conducted between January 2012 and March 2020. A total of 1,046 patients with acute MI who underwent primary percutaneous coronary intervention were divided into two groups according to denture use status. The primary outcomes included ischemic events (cardiovascular death, recurrent MI, and ischemic stroke) and major bleeding (Bleeding Academic Research Consortium type 3 or 5). Results Of the 1,046 patients with acute MI, 387 (37.0%) used dentures. An older age and prior MI were associated with an increased likelihood of denture use. During the mean 660-day follow-up period, ischemic and major bleeding events occurred in 169 (16.2%) and 102 (9.8%) patients, respectively. Denture use was associated with an increased risk of ischemic events, whereas no significant intergroup differences were observed in major bleeding outcomes. The results were similar among patients ≥75 years old. Conclusion More than one-third of the patients with acute MI wore dentures. Our findings suggest that denture use is significantly associated with an increased risk of ischemic events but not bleeding outcomes after acute MI.
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Yamashita et al. (2022) conducted an observational in Acute myocardial infarction (n=1,046). Denture use vs. No denture use was evaluated on Ischemic events (cardiovascular death, recurrent MI, and ischemic stroke) (HR 1.19, 95% CI 0.85-1.67, p=0.31). Denture use was associated with an increased unadjusted risk of ischemic events after acute myocardial infarction, but this was not significant after multivariable adjustment (HR 1.19).
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