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April 1, 2000Brain PathologyOpen Access

Neuroprotection by the Inhibition of Apoptosis

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Why the study?

Do apoptosis inhibitors prevent neuronal loss in acute and chronic neurodegenerative conditions?

Population

Patients and animal models with acute and chronic neurodegenerative conditions

Design

Review

Authors

GRGeorge S. RobertsonAdelaide Institute for Sleep HealthSCStephen J. CrockerUniversity of ConnecticutDNDonald W. NicholsonUniversity of New Brunswick

Discussion

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Overview

Apoptosis inhibitors merit further preclinical and clinical testing in neurodegeneration; leaves open human efficacy and safety.

Structured PICO

Do apoptosis inhibitors prevent neuronal loss in acute and chronic neurodegenerative conditions?

P
Population
Patients and animal models with acute and chronic neurodegenerative conditions (including stroke, spinal cord trauma, head injury, Alzheimer's disease, and spinal muscular atrophy)
I
Intervention
Apoptosis inhibitors (including peptide-based caspase inhibitors and inhibitor of apoptosis (IAP) family members like NAIP and XIAP)
O
Outcome
Prevention of neuronal loss (neuroprotection)

Apoptosis inhibitors, including caspase inhibitors and IAPs, show potential as therapeutic agents for preventing neuronal loss in acute and chronic neurodegenerative conditions.

Cite This Study

Robertson et al. (2000) studied this question.

synapsesocial.com/papers/6a7bf20e351d91d38cc64011https://doi.org/10.1111/j.1750-3639.2000.tb00262.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.1993 · 926 citations
  2. 2Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus1999 · 205 citations
  3. 3K‐252 Compounds: Modulators of Neurotrophin Signal Transduction1992 · 247 citations
  4. 4Staurosporine, K‐252a, and K‐252b Stabilize Calcium Homeostasis and Promote Survival of CNS Neurons in the Absence of Glucose1994 · 38 citations
  5. 5CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults1999 · 191 citations