Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 1986Biochemistry

Metal anthracycline complexes as a new class of anthracycline derivatives. Palladium(II)-adriamycin and palladium(II)-daunorubicin complexes: physicochemical characteristics and antitumor activity

View Full Paper
Ask AI
Bookmark
Share

Population

P-388 leukemia preclinical model

Comparison

Palladium-adriamycin and palladium-daunorubicin… vs Free drug (adriamycin/daunorubicin)

Design

Preclinical

Authors

MFMarina FialloUniversité Toulouse III - Paul SabatierAGArlette Garnier‐SuillerotCentre National de la Recherche Scientifique

Discussion

Loading...

Member takes

Overview

May support palladium-anthracycline complexes to limit cardiotoxicity; leaves open translation from P-388 leukemia models.

Structured PICO

P
Population
P-388 leukemia preclinical model
I
Intervention
Palladium(II)-adriamycin and palladium(II)-daunorubicin complexes
C
Comparator
Free drug (adriamycin/daunorubicin)
O
Outcome
Antitumor activity and physicochemical characteristics (complex formation, DNA interaction, electron flow catalysis)surrogate

Palladium(II) complexes of anthracyclines maintain antitumor activity while potentially avoiding the electron flow catalysis that is typically associated with anthracycline-induced cardiotoxicity.

Cite This Study

Fiallo et al. (1986) studied this question.

synapsesocial.com/papers/6a7bf20e351d91d38cc64012https://doi.org/10.1021/bi00352a028
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1NADH oxidation in submitochondrial particles protects respiratory chain activity against damage by adriamycin‐Fe3+1983 · 46 citations