Assessment of subclinical left ventricle myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved left ventricle ejection fraction

Tao Wang; Li Li; Jun Huang; Fan Li

doi:10.1186/s13098-021-00781-x

January 28, 2022Diabetology & Metabolic SyndromeOpen Access

Assessment of subclinical left ventricle myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved left ventricle ejection fraction

View Full Paper

Ask AI

Bookmark

Share

Why the study?

The study was conducted to assess subclinical LV myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved LVEF.

Does global myocardial work assessment detect subclinical LV myocardial dysfunction in T2DM patients with preserved LVEF compared to normal controls?

Structured PICO

Does global myocardial work assessment detect subclinical LV myocardial dysfunction in T2DM patients with preserved LVEF compared to normal controls?

P

Population

120 individuals, comprising 60 patients with type 2 diabetes mellitus (T2DM) and preserved left ventricle ejection fraction (LVEF), and 60 normal controls.

I

Intervention

Type 2 diabetes mellitus (T2DM) with preserved LVEF

C

Comparator

Normal controls

O

Outcome

Subclinical left ventricle myocardial dysfunction assessed by global myocardial work parameters (GLS, GWI, GCW, GWW, GWE) using speckle-tracking echocardiographysurrogate

Global myocardial work parameters derived from speckle-tracking echocardiography can effectively detect subclinical left ventricular myocardial dysfunction in patients with type 2 diabetes and preserved ejection fraction.

Implication

MW may detect subclinical LV dysfunction in T2DM with preserved LVEF; leaves open prognostic value and clinical utility.

Abstract

BACKGROUND: The purpose of this study was to assess subclinical left ventricle (LV) myocardial dysfunction using global myocardial work (MW) in type 2 diabetes mellitus (T2DM) patients with preserved left ventricle ejection fraction (LVEF). METHODS: Sixty T2DM patients and 60 normal controls were enrolled in the study. Apical 4-, 3- and 2-chamber views were acquired by two-dimensional echocardiography. Peak systolic myocardial global longitudinal strain (GLS), global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and myocardial work efficiency (GWE) were determined by speckle-tracking echocardiography (STE). RESULTS: The GLS values in the T2DM patients were significantly lower than those in normal controls (p < 0.001). The GWW in T2DM patients was significantly greater than that in normal controls, while GWI, GCW and GWE was significantly lower (p < 0.001). Receiver operating characteristic (ROC) analysis showed there were no significant different difference between GWW, GWE and GLS in the area under the curves (AUCs). In T2DM patients, fasting plasma glucose was positively correlated with GWW but negatively correlated with GWE, and GLS was negatively correlated with GWI and GCW. CONCLUSION: From the research, we found that global MW as new technique could detect the subclinical LV myocardial dysfunction and confirm that the impaired LV function in T2DM patients with preserved LV systolic function.