What question did this study set out to answer?

To investigate the association between the systemic inflammatory response index (SIRI) and clinical severity, hemodynamic parameters, and long-term clinical deterioration in idiopathic pulmonary arterial hypertension (IPAH).

January 1, 2024Journal of Inflammation ResearchOpen Access

Role of the Systemic Inflammatory Response Index in Predicting Disease Severity and Prognosis in Idiopathic Pulmonary Arterial Hypertension

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Why the study?

Evidence suggests a connection between the systemic inflammatory response index and heart failure prognosis, but its role in idiopathic pulmonary arterial hypertension is not well understood.

Does a higher systemic inflammatory response index (SIRI) predict clinical deterioration in patients with idiopathic pulmonary arterial hypertension?

Population

426 consecutive IPAH patients who underwent right heart catheterization at Fuwai Hospital

Comparison

SIRI > 0.741 vs SIRI ≤ 0.741

Design

Observational cohort study

Authors

LGLuyang GaoChinese Academy of Medical Sciences & Peking Union Medical College SZSicheng ZhangHarbin University of Science and Technology ZZZhihui ZhaoVascular / Pulmonary Vascular

Discussion

Member takes

Implication

SIRI may aid IPAH risk stratification; leaves open incremental prognostic value beyond standard markers in prospective validation.

Key Points

To investigate the association between the systemic inflammatory response index (SIRI) and clinical severity, hemodynamic parameters, and long-term clinical deterioration in idiopathic pulmonary arterial hypertension (IPAH).
Enrolled 426 consecutive patients with IPAH who underwent right heart catheterization at Fuwai Hospital between January 2013 and December 2020.
Calculated SIRI from peripheral blood cell counts and defined clinical deterioration as the primary outcome event.
Assessed prognostic utility using Spearman correlations, receiver operating characteristic curves, Kaplan-Meier survival curves, and multivariable Cox proportional hazards modeling.
SIRI correlated positively with N-terminal pro-brain natriuretic peptide, right ventricular end-diastolic diameter, pericardial effusion, mean pulmonary arterial pressure, and pulmonary vascular resistance, while correlating inversely with 6-minute walk distance.
Patients with SIRI > 0.741 experienced significantly higher rates of clinical deterioration compared to those with SIRI ≤ 0.741 (P < 0.001).
Adjusted Cox regression identified SIRI as an independent predictor of clinical worsening (hazard ratio 1.366, 95% CI 1.073–1.738, P = 0.011), offering incremental prognostic value beyond standard ESC/ERS risk scores.

Structured PICO

Does a higher systemic inflammatory response index (SIRI) predict clinical deterioration in patients with idiopathic pulmonary arterial hypertension?

Population

426 consecutive patients with idiopathic pulmonary arterial hypertension (IPAH) who underwent right heart catheterization at Fuwai Hospital

Intervention

Systemic inflammatory response index (SIRI) > 0.741

Comparator

SIRI ≤ 0.741

Outcome

Clinical deteriorationcomposite

SIRI is an independent predictor of clinical deterioration in patients with idiopathic pulmonary arterial hypertension, offering additional prognostic value beyond standard risk scores.

Cite This Study

Gao et al. (2024) studied this question.

synapsesocial.com/papers/6a7bfcf37cc40aa1f8df9dd6 https://doi.org/10.2147/jir.s434720

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Role of the Systemic Inflammatory Response Index in Predicting Disease Severity and Prognosis in Idiopathic Pulmonary Arterial Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Role of the Systemic Inflammatory Response Index in Predicting Disease Severity and Prognosis in Idiopathic Pulmonary Arterial Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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