Why the study?
Does the long-range correlation of glucose dynamics differ between diabetic patients and nondiabetic subjects?
Does the long-range correlation of glucose dynamics differ between diabetic patients and nondiabetic subjects?
Diabetic patients exhibit a breakdown of the normal long-range negative correlation in glucose dynamics, reflecting a lack of long-term stability in blood glucose homeostasis.
May indicate impaired glucose stability in diabetes; hypothesis-generating and requires longitudinal studies before clinical consideration.
Diurnal fluctuations in glucose levels continuously monitored during normal daily life are investigated using an extended random walk analysis, referred to as detrended fluctuation analysis (DFA), in 12 nondiabetic subjects and 15 diabetic patients. The DFA exponent alpha = 1.25 +/- 0.29 for healthy individuals in the "long-range" (>2 h) regime is shown to be significantly (P < 0.01) smaller than the reference "uncorrelated" value of alpha = 1.5, suggesting that the instantaneous net effects of the dynamical balance of glucose flux and reflux, causing temporal changes in glucose concentration, are long-range negatively correlated. By contrast, in diabetic patients, the DFA exponent alpha = 1.65 +/- 0.30 is significantly (P < 0.05) higher than that in nondiabetic subjects, evidencing a breakdown of the long-range negative correlation. It is suggested that the emergence of such positive long-range glucose correlations in diabetic patients-indicating that the net effects of the flux and reflux persist for many hours-likely reflects pathogenic mechanisms of diabetes, i.e., the lack of long-term stability of blood glucose and that the long-range negatively correlated glucose dynamics are functional in maintaining normal glucose homeostasis.
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Ogata et al. (2006) studied this question.
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