Reflex and Tonic Autonomic Markers for Risk Stratification in Patients With Type 2 Diabetes Surviving Acute Myocardial Infarction
Why the study?
Does severe autonomic failure predict mortality in patients with type 2 diabetes surviving acute myocardial infarction?
Population
481 patients with type 2 diabetes who survived acute myocardial infarction, aged ≤ 80 years, and presented…
Comparison
Severe autonomic failure, defined as coincidence… vs Patients without severe autonomic failure.
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
May inform risk stratification in diabetic post-MI patients; leaves open whether targeted interventions improve outcomes.
Structured PICO
Does severe autonomic failure predict mortality in patients with type 2 diabetes surviving acute myocardial infarction?
P
Population
481 patients with type 2 diabetes who survived acute myocardial infarction (MI), aged ≤ 80 years, and presented in sinus rhythm.
I
Intervention
Severe autonomic failure (SAF), defined as coincidence of abnormal autonomic reflex function (assessed by heart rate turbulence) and abnormal autonomic tonic activity (assessed by deceleration capacity of heart rate).
C
Comparator
Patients without severe autonomic failure.
O
Outcome
Total mortality at 5 years of follow-up.hard clinical
Combined abnormalities of autonomic reflex function and autonomic tonic activity strongly predict 5-year mortality in diabetic post-MI patients.
Cite This Study
Barthel et al. (2011) studied this question.