• Administration of cancer chemotherapeutic agents to humans and animals is frequently complicated by diarrhea and enterocolitis.Clostridium difficileand its toxin were found in the stools of two patients with colitis after chemotherapy for malignant neoplasms. Diarrhea in both patients resolved with oral vancomycin hydrochloride therapy.Clostridium difficilewas also isolated from several fomites within the room of one of these patients and also from the hands of his nurses. Based on these two recent experiences, we believe patients with cancer and diarrhea or signs suggestive of colitis should be studied for toxigenicC difficileand appropriate isolation techniques employed. (Arch Intern Med1982;142:333-335)
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William L. Henrich (1982) studied this question.