Why the study?
Existing clinical strategies face bottlenecks and challenges in the early detection and management of atherosclerosis.
Macrophage-targeted nanomedicine represents a promising emerging strategy for the early detection and targeted treatment of atherosclerosis.
Macrophage targeting in atherosclerosis faces persistent clinical bottlenecks; leaves open need for novel early diagnostics and therapies.
Atherosclerosis is the primary cause of cardiovascular diseases, such as myocardial infarction and stroke, which account for the highest death toll worldwide. Macrophage is the major contributor to atherosclerosis progression, and therefore, macrophage-associated pathological process is considered an extremely important target for the diagnosis and treatment of atherosclerosis. However, the existing clinical strategies still have many bottlenecks and challenges in atherosclerosis's early detection and management. Nanomedicine, using various nanoparticles/nanocarriers for medical purposes, can effectively load therapeutic agents, significantly improve their stability and accurately deliver them to the atherosclerotic plaques. In this review, we summarized the latest progress of the macrophage-targeted nanomedicine in the diagnosis and treatment of atherosclerosis, and their potential applications and clinical benefits are also discussed.
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Hu et al. (2022) studied this question.
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