Why the study?
Are plasma TNF-alpha levels elevated in asymptomatic and cardiomyopathic Chagas disease patients compared to controls?
Are plasma TNF-alpha levels elevated in asymptomatic and cardiomyopathic Chagas disease patients compared to controls?
Elevated TNF-alpha production in asymptomatic Chagas disease and its further increase in severe cardiomyopathy suggest it may play a role in disease progression prior to heart failure.
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TNF-alpha elevation tracks Chagas cardiomyopathy severity; leaves open its prognostic value and progression role pending longitudinal data.
Ferreira et al. (2003) studied this question.
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