February 12, 2018Journal of the American Heart AssociationOpen Access

“Malignant” Left Ventricular Hypertrophy Identifies Subjects at High Risk for Progression to Asymptomatic Left Ventricular Dysfunction, Heart Failure, and Death: MESA (Multi‐Ethnic Study of Atherosclerosis)

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Why the study?

Does malignant LVH predict progression to asymptomatic LV dysfunction, heart failure, and cardiovascular death in adults without known cardiovascular disease?

Population

4,985 individuals without prevalent cardiovascular disease from the MESA cohort

Comparison

Presence of malignant left ventricular hypertrophy vs No LVH and no elevated biomarkers

Design

Cohort

Follow-up

median 12.2 years

Authors

MPMatthew N. PetersAllen Institute for Artificial Intelligence SSStephen L. SeligerNorthwestern University RCRobert H. ChristensonGeneral Cardiology

Discussion

Member takes

Implication

Malignant LVH may identify high-risk adults without known cardiovascular disease; hypothesis-generating for targeted prevention trials.

Structured PICO

Does malignant LVH predict progression to asymptomatic LV dysfunction, heart failure, and cardiovascular death in adults without known cardiovascular disease?

Population

4,985 individuals without prevalent cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis) cohort

Intervention

Presence of malignant left ventricular hypertrophy (LVH combined with elevated high-sensitivity cardiac troponin T or amino-terminal pro-B-type natriuretic peptide)

Comparator

No LVH and no elevated biomarkers

Outcome

Incidence of heart failure, cardiovascular death, and asymptomatic LV dysfunction (LVEF <50% on repeat cardiac magnetic resonance at 10 years)hard clinical

Malignant LVH identifies a high-risk phenotype in individuals without known cardiovascular disease, strongly predicting progression to heart failure, cardiovascular death, and asymptomatic LV dysfunction.

Cite This Study

Peters et al. (2018) studied this question.

synapsesocial.com/papers/6a7c039f1f8f1eb7b8ed4ffa https://doi.org/10.1161/jaha.117.006619

Topics

HFrEF treatment Heart failure

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“Malignant” Left Ventricular Hypertrophy Identifies Subjects at High Risk for Progression to Asymptomatic Left Ventricular Dysfunction, Heart Failure, and Death: MESA (Multi‐Ethnic Study of Atherosclerosis)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

“Malignant” Left Ventricular Hypertrophy Identifies Subjects at High Risk for Progression to Asymptomatic Left Ventricular Dysfunction, Heart Failure, and Death: MESA (Multi‐Ethnic Study of Atherosclerosis)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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