Why the study?
Does mibefradil have less negative inotropic effect compared to nifedipine and verapamil in isolated failing human myocardium?
Population
Isolated, electrically driven left ventricular papillary muscle strips from failing human hearts obtained…
Comparison
Mibefradil (Ro 40-5967) vs Nifedipine and verapamil
Design
Preclinical
Authors
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May indicate better tolerability in heart failure; leaves open clinical relevance of in vitro findings.
Does mibefradil have less negative inotropic effect compared to nifedipine and verapamil in isolated failing human myocardium?
Mibefradil exhibits significantly less negative inotropic effect on failing human myocardium in vitro compared to nifedipine and verapamil, suggesting a potentially greater therapeutic index.
Cremers et al. (1997) studied this question.
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