Key result
Cerebral ischemia features increased cerebral hematocrit alongside low flow and high volume on SPECT.
Observational
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Single-photon emission computed tomography (SPECT) was used for the measurement of regional cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral hematocrit (Hct). CBF was measured using N-isopropyl-p-I-123-Iodoamphetamine. CBV was measured by both RBC tracer (Tc-99m RBC) and plasma tracer (Tc-99m human serum albumin) and cerebral hematocrit (Hct) was calculated. In normals, the cerebral-to-large vessel Hct ratio was 75.9%. Isovolemic hemodilution in patients with high Hct tended to increase the cerebral-to-large vessel Hct ratio. Low CBF, high CBV and slow cerebral blood mean transit time (MTT by dynamic CT scanning) was seen during the acute stage of completed infarction and during the symptom-free interval of TIA. Cerebral Hct was increased in the ischemic region of poor prognosis.
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Sakai et al. (1989) conducted an observational in Cerebral ischemia (completed infarction and transient ischemic attack). Single-photon emission computed tomography (SPECT) and isovolemic hemodilution vs. Normal controls was evaluated on Regional cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral hematocrit (Hct). SPECT showed a 75.9% cerebral-to-large vessel Hct ratio in normals, while cerebral ischemia featured low CBF, high CBV, and increased cerebral Hct in regions of poor prognosis.
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