What question did this study set out to answer?

To prospectively analyze sequential humoral and cellular immune alterations in severe burn patients and identify defects linked to post-injury infection.

December 1, 1978Annals of SurgeryOpen Access

A Sequential, Prospective Analysis of Immunologic Abnormalities and Infection Following Severe Thermal Injury

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Authors

JAJan AlexanderNorwegian Institute of Public Health COCora K. OgleShriners Hospitals for Children - Cincinnati JSJ. D. StinnettMedical University of South Carolina

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Implication

Prospective cohort study observes impaired neutrophil bactericidal function in severe burn patients, highlighting neutrophil dysfunction as the primary driver of post-burn bacteremia.

Key Points

To prospectively analyze sequential humoral and cellular immune alterations in severe burn patients and identify defects linked to post-injury infection.
Conducted a prospective, sequential analysis of immune function in 20 burn patients with injuries involving ≥45% total body surface area.
Evaluated neutrophil bactericidal activity against Staphylococcus aureus 502A, chemotaxis, opsonic index, complement components (C3, Factor B, properdin), IgG levels, and lymphocyte responses to phytohemagglutinin over time.
Neutrophil bactericidal activity was significantly impaired in infected patients compared to noninfected patients, while abnormal neutrophil chemotaxis correlated poorly with infection.
Serum IgG, properdin, and C3 returned to normal levels after postburn day nine, Factor B doubled within three weeks, and five of 19 bacteremic episodes showed evidence of opsonic protein consumption.
Isolated patient lymphocytes showed normal response to phytohemagglutinin, but patient serum significantly inhibited the proliferative response of healthy lymphocytes.

Cite This Study

Alexander et al. (1978) studied this question.

synapsesocial.com/papers/6a7c05ffeac460320975d74e https://doi.org/10.1097/00000658-197812000-00016

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Implication

Prospective cohort study observes impaired neutrophil bactericidal function in severe burn patients, highlighting neutrophil dysfunction as the primary driver of post-burn bacteremia.

A Sequential, Prospective Analysis of Immunologic Abnormalities and Infection Following Severe Thermal Injury

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Implication

Key Points

Cite This Study

A Sequential, Prospective Analysis of Immunologic Abnormalities and Infection Following Severe Thermal Injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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