Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 16, 2020Molecular Therapy — Nucleic AcidsOpen Access

CCNL overexpression upregulated FOXO1 expression, promoted cell apoptosis, reduced glucose transport capability, and impaired mitochondrial function, effects that were partially abolished by silencing FOXO1.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Polycystic ovary syndrome is a common endocrine and metabolic disease, but the roles of long non-coding RNAs in its pathogenesis require clarification.

Does lnc-CCNL1-3:1 overexpression promote granulosa cell apoptosis and suppress glucose uptake in PCOS cell models?

Population

Human luteinized granulosa cells from women with and without PCOS, and KGN cells

Comparison

CCNL overexpression vs control, and silencing FOXO1

Design

In vitro laboratory study

Authors

JHJiayu HuangJZJun ZhaoXGXueying Geng

Discussion

Loading...

Member takes

Overview

CCNL dysregulation in PCOS hLGCs suggests a pathogenic role; leaves open clinical translation pending prospective validation.

Structured PICO

Does lnc-CCNL1-3:1 overexpression promote granulosa cell apoptosis and suppress glucose uptake in PCOS cell models?

P
Population
Human luteinized granulosa cells (hLGCs) derived from women with and without polycystic ovary syndrome (PCOS), and KGN cells
I
Intervention
Overexpression of lncRNA lnc-CCNL1-3:1 (CCNL)
C
Comparator
Control cells / silencing of FOXO1
O
Outcome
Granulosa cell apoptosis, mitochondrial function, and glucose uptakesurrogate

lnc-CCNL1-3:1 promotes granulosa cell apoptosis and suppresses glucose uptake by interacting with FOXO1, suggesting it acts as a facilitator in PCOS pathologies such as follicular atresia and insulin resistance.

Cite This Study

Huang et al. (2020) studied this question.

synapsesocial.com/papers/6a7c0fc84fcef545fadf9d77https://doi.org/10.1016/j.omtn.2020.12.008
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long non-coding RNA H19 is associated with polycystic ovary syndrome in Chinese women: a preliminary study2019 · 64 citations
  2. 2Molecular mechanisms of ROS production and oxidative stress in diabetes2016 · 881 citations
  3. 3Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR2000 · 348 citations
  4. 4Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS)2019 · 119 citations
  5. 5Polycystic Ovary Syndrome Is Associated with Tissue-Specific Differences in Insulin Resistance2008 · 129 citations