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January 1, 2019Endocrine JournalOpen Access

lncRNA H19 expression was significantly higher in PCOS cases than controls, and positively correlated with fasting plasma glucose levels.

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Why the study?

Little was known regarding whether there was an association between lncRNA H19 and polycystic ovary syndrome.

Is long non-coding RNA H19 expression associated with polycystic ovary syndrome and its endocrine variables in Chinese women?

Population

Patients with PCOS and normal controls

Comparison

Patients with PCOS vs normal controls

Design

Case-control study

Authors

LQLi QinCHChuican HuangXYXiumin Yan

Discussion

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Member takes

Overview

Elevated H19 may support PCOS biomarker research; case-control data leaves clinical utility and causality open.

Structured PICO

Is long non-coding RNA H19 expression associated with polycystic ovary syndrome and its endocrine variables in Chinese women?

P
Population
Chinese women with polycystic ovary syndrome (PCOS) and normal controls
I
Intervention
lncRNA H19 expression levels (measured in peripheral blood leukocytes)
C
Comparator
Normal controls
O
Outcome
Risk of PCOS and correlation with endocrine variables (fasting plasma glucose, total testosterone, insulin resistance)surrogate

Elevated lncRNA H19 expression is associated with PCOS and correlates with fasting plasma glucose, suggesting it may serve as a biomarker for early endocrine and metabolic disorders in susceptible individuals.

Cite This Study

Qin et al. (2019) studied this question.

synapsesocial.com/papers/6a72f796e188acf788cf2c5chttps://doi.org/10.1507/endocrj.ej19-0004
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