Why the study?
Does doxorubicin induce inflammatory modulation and metabolic dysregulation in diabetic skeletal muscle in mice?
Population
db/db diabetic and db/+ non-diabetic mice
Comparison
Doxorubicin intraperitoneally injected at a dose… vs Same volume of saline injected intraperitoneally
Design
Preclinical, randomly assigned
Authors
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May inform doxorubicin myotoxicity mechanisms in diabetic muscle; hypothesis-generating and requires human validation before clinical consideration.
Does doxorubicin induce inflammatory modulation and metabolic dysregulation in diabetic skeletal muscle in mice?
Doxorubicin induces inflammatory modulation and shifts metabolism to anaerobic glycolysis in diabetic skeletal muscle, highlighting mechanisms of DOX-induced myotoxicity.
Supriya et al. (2016) studied this question.
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